| 2021-09-01 | Chris Ballard Meets Media Ahead Of 2021 Season |
| 2021-09-02 | Media Availability: Carson Wentz, September 2 |
| 2021-09-02 | Media Availability: Frank Reich, September 2 |
| 2021-09-02 | Media Availability: Darius Leonard, September 2 |
| 2021-09-03 | Colts Camp Weekly: Focused On Week 1 |
| 2021-09-06 | Frank Reich: Colts Vs. Seahawks, Week 1 |
| 2021-09-06 | Nyheim Hines: Colts Vs. Seahawks, Week 1 |
| 2021-09-06 | Ryan Kelly: Colts Vs. Seahawks, Week 1 |
| 2021-09-07 | Welcome Back, Colts Fans |
| 2021-09-07 | OC Marcus Brady: Colts vs. Seahawks, Week 1 |
| 2021-09-08 |
Mid-Week Update: Frank Reich, Colts vs. Seahawks |
| 2021-09-08 | Carson Wentz: Colts vs. Seahawks, Week 1 |
| 2021-09-08 | DeForest Buckner: Colts vs. Seahawks, Week 1 |
| 2021-09-09 | Colts 2021 Season Trailer |
| 2021-09-09 | Darius Leonard: Colts Vs. Seahawks, Week 1 |
| 2021-09-09 | Julién Davenport: Colts Vs. Seahawks, Week 1 |
| 2021-09-10 | NFLN | Michael Strachan Details His Journey From Bahamas To The NFL |
| 2021-09-10 | Week 1 Final Update: Frank Reich, Colts vs. Seahawks |
| 2021-09-10 | Jonathan Taylor: Colts Vs. Seahawks, Week 1 |
| 2021-09-10 | Locker Talk: Colts Vs. Seahawks | Week 1 |
| 2021-09-11 | Game Preview: Colts Vs. Seahawks |
| 2021-09-12 | HIGHLIGHT | Parris Campbell Makes Tough 24-Yard Grab |
| 2021-09-12 | HIGHLIGHT | Zach Pascal Catches 10-Yard Touchdown From Carson Wentz |
| 2021-09-12 | HIGHLIGHT | Russell Wilson Can't Escape Khari Willis On 10-Yard Sack |
| 2021-09-12 | HIGHLIGHT | DeForest Buckner Comes Up With Third-Down Sack On Russell Wilson |
| 2021-09-12 | HIGHLIGHT | Kwity Paye Recovers Chris Carson's Fumble |
| 2021-09-12 | HIGHLIGHT | Carson Wentz Finds Zach Pascal For 11-Yard Touchdown |
| 2021-09-12 | Colts vs. Seahawks Postgame: Frank Reich |
| 2021-09-12 | Colts vs. Seahawks Postgame: Carson Wentz |
| 2021-09-12 | Colts Vs. Seahawks Postgame: Ryan Kelly |
| 2021-09-12 | Colts Vs. Seahawks Postgame: Kenny Moore II |
| 2021-09-12 | Colts Vs. Seahawks Postgame: Darius Leonard |
| 2021-09-12 | HIGHLIGHTS | Carson Wentz Best Plays From Colts Debut |
| 2021-09-13 | Frank Reich: Seattle Seahawks, Week 1 Review |
| 2021-09-13 | Press Conference: Nyheim Hines, September 13 |
| 2021-09-13 | Press Conference: Julian Blackmon, September 13 |
| 2021-09-14 | Kicking The Stigma: Sam Ehlinger |
| 2021-09-14 | OC Marcus Brady: Colts Vs. Rams, Week 2 |
| 2021-09-14 | DC Matt Eberflus: Colts Vs. Rams, Week 2 |
| 2021-09-15 | Carson Wentz: Colts Vs. Rams, Week 2 |
| 2021-09-15 |
Mid-Week Update: Frank Reich, Colts Vs. Rams |
| 2021-09-15 | DeForest Buckner: Colts Vs. Rams, Week 2 |
| 2021-09-15 | Eric Fisher: Colts Vs. Rams, Week 2 |
| 2021-09-15 | NFLN | Colts Vs. Rams Preview | Week 2 |
| 2021-09-16 | Zach Pascal: Colts Vs. Rams, Week 2 |
| 2021-09-16 | Bobby Okereke: Colts Vs. Rams, Week 2 |
| 2021-09-16 | Zaire Franklin: Colts Vs. Rams, Week 2 |
| 2021-09-17 | HARD KNOCKS IN SEASON: THE INDIANAPOLIS COLTS Teaser Trailer |
| 2021-09-17 | Fueling The Colts: Preparing Lucas Oil Stadium |
| 2021-09-17 | Darius Leonard: Colts Vs. Rams, Week 2 |
| 2021-09-17 | Quenton Nelson: Colts Vs. Rams, Week 2 |
| 2021-09-17 | Locker Talk: Colts Vs. Rams | Week 2 |
| 2021-09-18 | Game Preview: Colts Vs. Rams |
| 2021-09-19 | Pregame Insights: Frank Reich Ahead Of Week 2 Matchup |
| 2021-09-19 | HIGHLIGHT | Carson Wentz Finds Michael Pittman Jr. On 42-Yard Pass |
| 2021-09-19 | HIGHLIGHT | Khari Willis Picks Off Matthew Stafford's Overthrow |
| 2021-09-19 | HIGHLIGHT | Zach Pascal Catches Touchdown From Carson Wentz |
| 2021-09-19 | HIGHLIGHT | Jack Doyle Finds Soft Spot In Rams' Defense For Two-Point Grab |
| 2021-09-19 | HIGHLIGHT | Ashton Dulin Recovers Johnny Hekker Fumble In Endzone |
| 2021-09-19 | HIGHLIGHT | Jack Doyle Finds Space In Rams' Secondary For 34-Yard Gain |
| 2021-09-19 | Colts Vs. Rams Postgame: Frank Reich |
| 2021-09-19 | Colts Vs. Rams Postgame: Jacob Eason |
| 2021-09-19 | Colts Vs. Rams Postgame: Ryan Kelly |
| 2021-09-19 | Colts Vs. Rams Postgame: Quenton Nelson |
| 2021-09-19 | HIGHLIGHTS | Every Michael Pittman Catch From 123-Yard Day | Week 2 |
| 2021-09-19 | Colts Vs. Rams Postgame: Michael Pittman Jr. |
| 2021-09-20 | Edgerrin James and Peyton Manning Receive Their Hall Of Fame Rings |
| 2021-09-20 | Press Conference: Kwity Paye, September 20 |
| 2021-09-20 | Press Conference: Jack Doyle, September 20 |
| 2021-09-20 | Frank Reich: Los Angeles Rams, Week 2 Review |
| 2021-09-21 | OC Marcus Brady: Colts Vs. Titans, Week 3 |
| 2021-09-21 | Peyton Manning, Edgerrin James Hall Of Fame Ring Ceremony Recap |
| 2021-09-21 | Colts Continue Kicking The Stigma Initiative |
| 2021-09-22 | DeForest Buckner: Colts at Titans, Week 3 |
| 2021-09-22 |
Carson Wentz: Colts at Titans, Week 3 |
| 2021-09-22 | NFLN | Colts At Titans Preview | Week 3 |
| 2021-09-23 | Pick Six: Week 3 Questions |
| 2021-09-23 | Darius Leonard: Colts at Titans, Week 3 |
| 2021-09-23 | Brett Hundley: Colts at Titans, Week 3 |
| 2021-09-24 | Week 3 Final Update: Frank Reich, Colts at Titans |
| 2021-09-24 | Xavier Rhodes: Colts at Titans, Week 3 |
| 2021-09-24 | Michael Pittman Jr.: Colts at Titans, Week 3 |
| 2021-09-24 | Locker Talk: Colts At Titans | Week 3 |
| 2021-09-25 | Game Preview: Colts At Titans |
| 2021-09-26 | Pregame Insights: Frank Reich Ahead Of Matchup In Tennessee |
| 2021-09-26 | HIGHLIGHT | Bobby Okereke Flies Into Backfield Unblocked For Sack |
| 2021-09-26 | HIGHLIGHT | Darius Leonard Intercepts Ryan Tannehill |
| 2021-09-26 | HIGHLIGHT | Nyheim Hines Gets The Edge For Pylon-Reach TD |
| 2021-09-26 | HIGHLIGHT | Kenny Moore II Comes Up With Interception On Tipped Pass |
| 2021-09-26 | HIGHLIGHT | Rock Ya-Sin Forces, Recovers Nick Westbrook Fumble |
| 2021-09-26 | HIGHLIGHT | Nyheim Hines Catches For 36-yard Gain |
| 2021-09-26 | Colts at Titans Postgame: Zaire Franklin |
| 2021-09-26 | Colts at Titans Postgame: Nyheim Hines |
| 2021-09-26 | Colts at Titans Postgame: Darius Leonard |
| 2021-09-27 | Colts at Titans Postgame: DeForest Buckner |
| 2021-09-27 | Colts at Titans Postgame: Frank Reich |
| 2021-09-27 | Press Conference: Kenny Moore II, September 27 |
| 2021-09-27 | Press Conference: Nyheim Hines, September 27 |
| 2021-09-27 | Frank Reich: Tennessee Titans, Week 3 Review |
| 2021-09-28 | OC Marcus Brady: Colts at Dolphins, Week 4 |
| 2021-09-28 | DC Matt Eberflus: Colts at Dolphins, Week 4 |
| 2021-09-29 | Mid-week Update: Frank Reich, Colts at Dolphins |
| 2021-09-29 | DeForest Buckner: Colts at Dolphins, Week 4 |
| 2021-09-29 | Al-Quadin Muhammad: Colts at Dolphins, Week 4 |
| 2021-09-29 | NFLN | Colts at Dolphins Preview | Week 4 |
| 2021-09-30 | Darius Leonard: Colts at Dolphins, Week 4 |
| 2021-09-30 | Eric Fisher: Colts at Dolphins, Week 4 |
| 2021-09-30 | Ryan Kelly: Colts at Dolphins, Week 4 |
| 2021-09-30 | Marlon Mack: Colts at Dolphins, Week 4 |
| 2021-09-30 | Jonathan Taylor: Colts at Dolphins, Week 4 |
