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Indianapolis Colts head coach Frank Reich speaks with the media to wrap up the team's second week of the regular season.

Indianapolis Colts tight end Jack Doyle speaks with the media following the team's walk through.

Indianapolis Colts defensive end Kwity Paye speaks with the media following the team's walk through.

Indianapolis Colts wide receiver Michael Pittman Jr. speaks with the media following the team's loss to the Los Angeles Rams.

Indianapolis Colts quarterback Carson Wentz speaks with the media following the team's loss to the Los Angeles Rams.

Indianapolis Colts defensive back Khari Willis speaks with the media following the team's loss to the Los Angeles Rams.

Watch every catch from Indianapolis Colts wide receiver Michael Pittman's 123-yard day in Week 2 of the 2021 season.

Indianapolis Colts offensive lineman Quenton Nelson speaks with the media following the team's loss to the Los Angeles Rams.

Indianapolis Colts offensive lineman Ryan Kelly speaks with the media following the team's loss to the Los Angeles Rams.

Indianapolis Colts quarterback Jacob Eason speaks with the media following the team's loss to the Los Angeles Rams.

Indianapolis Colts head coach Frank Reich speaks with the media following the team's loss to the Los Angeles Rams.

Indianapolis Colts tight end Jack Doyle finds space in the Los Angeles Rams' secondary for 34-yard catch and run.

Indianapolis Colts wide receiver Ashton Dulin recovers a Johnny Hekker fumble in the end zone vs. Los Angeles Rams.

Former Indianapolis Colts greats Peyton Manning and Edgerrin James spoke with the media after receiving their Hall of Fame rings during the team's Week 2 matchup with the Rams.

Indianapolis Colts tight end Jack Doyle finds soft spot in the Los Angeles Rams' defense for two-point grab.

Indianapolis Colts wide receiver Zach Pascal twists to snag third TD of '21 on laser from quarterback Carson Wentz.

Indianapolis Colts safety Khari Willis picks off Los Angeles Rams quarterback Matthew Stafford's overthrow over the middle.

Indianapolis Colts quarterback Carson Wentz uses every launch code available on this 42-yard dime to WR Michael Pittman Jr.

NFL Network's Steve Wyche shows Indianapolis Colts' "Kicking the Stigma" warm-up T-shirts before Week 2.

Indianapolis Colts head coach Frank Reich catches up with Larra Overton to discuss his team's matchup with the Los Angeles Rams in Week 2.

Get prepared for the Indianapolis Colts second game of the 2021 regular season as they host the Los Angeles Rams.

Indianapolis Colts players meet with the media ahead of their week 1 matchup with the Seattle Seahawks.

Indianapolis Colts offensive lineman Quenton Nelson speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Indianapolis Colts linebacker Darius Leonard speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Indianapolis Colts head coach Frank Reich gives a final injury update ahead of the team's matchup with the Los Angeles Rams.

Indianapolis Colts defensive back Khari Willis speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Get a behind the scenes look at the intricate process of converting Lucas Oil Stadium from a concert venue to an NFL football stadium, and learn what goes into getting the Indianapolis Colts' home ready for Gameday each Sunday.

HARD KNOCKS IN SEASON: THE INDIANAPOLIS COLTS premieres Wednesday, November 17 at 10 p.m. ET.

HBO Sports, NFL Films and the Indianapolis Colts team up for the first-ever in-season presentation of HARD KNOCKS IN SEASON: THE INDIANAPOLIS COLTS.

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Indianapolis Colts linebacker Bobby Okereke speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Indianapolis Colts wide receiver Zach Pascal speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Indianapolis Colts linebacker Darius Leonard shares his support of the team's Kicking The Stigma initiative to support mental health.

Pick Six presented by Caesars Sportsbook is a free-to-play game on the Colts App

Each week, fans will answer a series of six questions with their predictions for the game and compete for their chance to win exclusive autographed items and other Colts prizes. All players will also be entered for a chance to win a VIP trip to a Caesars property in Las Vegas. Enter today in the Colts mobile app and play each week all season long.

Must be 21 or older to participate.

Here's everything you need to know before the Los Angeles Rams take on the Indianapolis Colts in Week 2 of the 2021 NFL season.

Indianapolis Colts offensive lineman Eric Fisher speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Indianapolis Colts defensive lineman DeForest Buckner speaks with the media ahead of the team's matchup with the Los Angeles Rams.

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Indianapolis Colts quarterback Carson Wentz speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Relive the best moments from the HOF enshrinement weekend for Peyton Manning and Edgerrin James.

Indianapolis Colts defensive coordinator Matt Eberflus speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Indianapolis Colts offensive coordinator Marcus Brady speaks with the media ahead of the team's matchup with the Los Angeles Rams.

Indianapolis Colts linebacker Darius Leonard was wired for sound for the team's Week 1 matchup with the Seattle Seahawks.

Indianapolis Colts quarterback Sam Ehlinger talks about his personal experience with mental health and how important it is to talk about what you are going through.

The Colts and the Irsay family has launched Kicking the Stigma, a comprehensive initiative to raise awareness about mental health disorders and to remove the shame and stigma too often associated with these illnesses.

To learn more, visit Colts.com/KTS.

Indianapolis Colts defensive back Julian Blackmon speaks with the media following the team's Week 1 loss to the Seattle Seahawks.

Indianapolis Colts running back Nyheim Hines speaks with the media following the team's Week 1 loss to the Seattle Seahawks.

Indianapolis Colts head coach Frank Reich shares a final update with the media following the Colts Week 1 loss to the Seattle Seahawks.

Indianapolis Colts quarterback Carson Wentz's best plays from Colts Debut vs Seahawks during Week 1 of the 2021 season.

Indianapolis Colts linebacker Darius Leonard speaks with the media following the team's loss to the Seattle Seahawks.

Indianapolis Colts defensive back Kenny Moore II speaks with the media following the team's loss to the Seattle Seahawks.

Indianapolis Colts center Ryan Kelly speaks with the media following the team's loss to the Seattle Seahawks.

Indianapolis Colts quarterback Carson Wentz speaks with the media following the team's loss to the Seattle Seahawks.

Indianapolis Colts head coach Frank Reich speaks with the media following the team's loss to the Seattle Seahawks.

Indianapolis Colts quarterback Carson Wentz finds wide receiver Zach Pascal for an 11-yard touchdown against the Seattle Seahawks.

Indianapolis Colts defensive end Kwity Paye recovers running back Chris Carson's fumble against Seattle Seahawks.

Indianapolis Colts defensive tackle DeForest Buckner reintroduces himself to former NFC West rival Seattle Seahawks quarterback Russell Wilson for sack.

Seattle Seahawks quarterback Russell Wilson can't escape Indianapolis Colts safety Khari Willis, Colts on 10-yard sack.

Indianapolis Colts wide receiver Zach Pascal hauls in a bullet from quarterback Carson Wentz to score a 10-yard touchdown vs. Seattle.

Indianapolis Colts wide receiver Parris Campbell hangs on through contact for tough 24-yard grab.

Indianapolis Colts head coach Frank Reich speaks with Larra Overton about what he wants to see from his team ahead of their Week 1 matchup with the Seattle Seahawks.

Get prepared for the Indianapolis Colts first game of the 2021 regular season as they host the Seattle Seahawks.