OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Luke Tenuta
- LG: Quenton Nelson
- C: Tanor Bortolini, Danny Pinter
- RG: Matt Goncalves, Dalton Tucker
- RT: Braden Smith, Jalen Travis
- TE: Tyler Warren, Mo Alie-Cox, Drew Ogletree, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce, Adonai Mitchell
- QB: Daniel Jones, Anthony Richardson Sr., Riley Leonard
- RB: Jonathan Taylor, Tyler Goodson OR DJ Giddens
- Taylor had 17 carries for 102 yards and three touchdowns in the Colts' Week 3 win over the Tennessee Titans.
- Jones completed 18-of-24 passes for 228 yards and a touchdown (to Michael Pittman Jr.) against the Titans.
- Pierce left the game with a concussion and is currently in concussion protocol.
DEFENSE
- DE: Kwity Paye, Tyquan Lewis, JT Tuimoloau
- DT: DeForest Buckner, Neville Gallimore, Adetomiwa Adebawore
- NT: Grover Stewart, Eric Johnson II
- DE: Laiatu Latu, Samson Ebukam
- WLB: Joe Bachie, Cameron McGrone, Segun Olubi
- MLB: Zaire Franklin, Chad Muma, Austin Ajiake
- CB: Charvarius Ward Sr. Johnathan Edwards
- FS: Camryn Bynum, Rodney Thomas II
- SS: Nick Cross, Daniel Scott
- N: Kenny Moore II, Mekhi Blackmon
- CB: Xavien Howard
- Moore recorded his fourth career pick-six against the Titans. He later exited the game with a calf injury.
- As a whole, the Colts had four sacks and seven quarterback hits against the Titans. Lewis (2), Paye (1) and Gallimore (1) each recorded sacks.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Spencer Shrader
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Anthony Gould, Ashton Dulin
- PR: Anthony Gould, Josh Downs
- Shrader was 2-for-3 on field goal attempts against the Titans, making a 24-yarder and a 36-yarder and missing what would have been a career-long 51-yard kick.
- Sanchez finally punted on Sunday, after 20 straight drives without a punt.
