Game Center

The Colts prepare for their first preseason game of 2022.

Go behind the scenes at Highmark Stadium as the Indianapolis Colts traveled to Buffalo for the first preseason matchup of the year versus the Buffalo Bills.

The Colts opened their 2022 preseason with a 27-24 loss to the Buffalo Bills on Saturday at Highmark Field, but there was plenty more to the game than the final score. Here are five big things we learned from the Colts' preseason curtain-lifter:

JJ Stankevitz and Bill Brooks discuss our first look at the Indianapolis Colts in 2022. The team opened their preseason in Buffalo.

Woods, the third-round tight end from Virginia, caught the touchdown from quarterback Sam Ehlinger in the third quarter of the Colts' preseason opener against the Buffalo Bills on Saturday. 

The Colts' offensive starters – save for running back Jonathan Taylor – played the entire first quarter and into the second quarter to kick off the 2022 preseason on Saturday against the Buffalo Bills. 

Head coach Frank Reich meets with the media following Saturday's game against the Buffalo Bills.

Quarterback Matt Ryan meets with the media following Saturday's game against the Buffalo Bills.

Watch the Indianapolis Colts' top plays vs. the Buffalo Bills during NFL Preseason Week 1.

Watch the game highlights of the Indianapolis Colts vs. Buffalo Bills during Week 1 of the 2022 NFL Preseason.

The Colts return to action in the first game of the preseason in a matchup against the Buffalo Bills.

Indianapolis Colts quarterback Sam Ehlinger throws a 12-yard touchdown strike to tight end Michael Jacobson against the Buffalo Bills.

Indianapolis Colts linebacker Sterling Weatherford grabs an interception against the Buffalo Bills.

Indianapolis Colts quarterback Sam Ehlinger throws an 11-yard touchdown pass to Jelani Woods.

Indianapolis Colts running back Ty'Son Williams hauls in a 15-yard touchdown reception from quarterback Nick Foles against the Buffalo Bills.

Indianapolis Colts cornerback Isaiah Rodgers records his second turnover and his team's fourth of the first half against the Buffalo Bills.

Indianapolis Colts defensive end Ben Banogu records a sack against the Buffalo Bills.

Indianapolis Colts defensive end Kameron Cline forces Buffalo Bills quarterback Case Keenum to fumble for his team's third takeaway of the half.

Cornerback Isaiah Rodgers records the Indianapolis Colts second takeaway against the Buffalo Bills.

The Colts take the field for warmups at Highmark Stadium ahead of their preseason opener versus Buffalo.

The Indianapolis Colts have arrived at Highmark Stadium ahead of their preseason game 1 matchup versus the Buffalo Bills.

Head Coach Frank Reich's pregame interview with Larra Overton, ahead of the 2022 preseason opener in Buffalo.

Check out photos of the team as they board their first flight of the season ahead of their preseason matchup versus the Buffalo Bills.

Matt Ryan and members of the Colts' first-team offense will play about a quarter in Saturday's preseason opener against the Buffalo Bills, which kicks off at 4 p.m. at Highmark Stadium. Here's what you need to know before the Colts' first preseason game of 2022:

The Colts haven't firmly decided on a plan for how long other players will play – if they play at all – but head coach Frank Reich said Wednesday quarterback Matt Ryan will play some or all of the first quarter in Buffalo on Saturday.