The Indianapolis Colts will host the San Francisco 49ers in Week 5. The game time is set for 1:00 p.m. ET on Sunday, Oct. 8, at Lucas Oil Stadium.
The contest will mark the 44th all-time regular season meeting between the teams, with Indianapolis leading the series, 25-18. The last matchup between the teams came on Sept. 22, 2013, when the Colts defeated the 49ers, 27-7, at Candlestick Park.
During halftime of the contest, the Colts will honor quarterback Peyton Manning in a halftime ceremony. Manning's No. 18 will be the first from the Indianapolis era to be retired and he will be inducted into the team's Ring of Honor.
Last week, Indianapolis faced the Seattle Seahawks on the road on NBC's Sunday Night Football and were defeated, 46-18.
The Seahawks got the first points on the board and took a 3-0 lead midway through the first quarter. The Colts countered when rookie cornerback Nate Hairston sacked Seattle quarterback Russell Wilson in the end zone for a safety.
After the Seahawks returned an interception for a touchdown, the Colts scored 13 unanswered points when running back Robert Turbin and wide receiver Donte Moncrief each scored touchdowns to give Indianapolis a 15-10 halftime advantage.
The second half had a different storyline as Seattle held the Colts to three points while scoring 36 points in the third and fourth quarters en route to a 46-18 win.
Defensively, Indianapolis forced two interceptions by safeties Malik Hooker and Matthias Farley. Inside linebacker Jon Bostic led the team with 12 tackles (five solo) and defensive tackle Johnathan Hankins and outside linebacker Jabaal Sheard each tallied a sack.
