Indianapolis Colts vs. San Francisco 49ers | Game Center

Quarterback Philip Rivers was mic'd up for Monday Night Football in Week 16 versus the San Francisco 49ers.

Colts Roundtable Live this week breaks down the Colts' 48-27 loss to the 49ers on Monday Night Football. Rick Venturi and Joe Reitz join Matt Taylor as they recap the game film on Tale of the Tape  (13:25), discuss the hard truths the Colts are facing as they currently sit on the outside looking in for the playoffs with just two games remaining (26:45) and answer fan questions from the Mailbag (43:25).

Head coach Shane Steichen meets with the media Tuesday to recap the Colts' loss to the 49ers on Monday Night Football in Week 16 of the 2025 season.

Defensive coordinator Lou Anarumo meets with the media Tuesday to recap the Colts' loss to the 49ers on Monday Night Football in Week 16 of the 2025 season.

Special teams coordinator Brian Mason meets with the media Tuesday to recap the Colts' loss to the 49ers on Monday Night Football in Week 16 of the 2025 season.

Rivers completed 23-of-45 passes for 277 yards and two touchdowns on Monday night.

Casey Vallier is joined by Amanda Foster to discuss the Colts' 48-27 loss to the San Francisco 49ers on Monday Night Football, first highlighting Philip Rivers' statement outing and Alec Pierce's career day before getting into the Colts' run game struggles and the problems the Colts defense faced against a talented 49ers offense. They dive into the locker room's perspective on the loss before quickly outlining the outlook for the final two weeks of the regular season.

Casey Vallier is joined by Amanda Foster to discuss the Colts' 48-27 loss to the San Francisco 49ers on Monday Night Football, first highlighting Philip Rivers' statement outing (1:28) and Alec Pierce's career day (5:30) before getting into the Colts' run game struggles (8:15) and the problems the Colts defense faced against a talented 49ers offense (11:00). They dive into the locker room's perspective on the loss (15:45) before quickly outlining the outlook for the final two weeks of the regular season (18:00).

The Colts fell to the 49ers in week 16 48-27. Here are the best moments from the game from the Ascension St. Vincent radio network.

Head coach Shane Steichen speaks with the media following the Colts' 48-27 loss to the 49ers in Week 16.

Quarterback Philip Rivers speaks with the media following the Colts' 48-27 loss to the 49ers in Week 16.

Tight end Mo Alie-Cox and wide receiver Alec Pierce speak with the media following the Colts' 48-27 loss to the 49ers in Week 16.

Watch the best plays from Indianapolis Colts quarterback Philip Rivers' 277-yard, two-touchdown game against the San Francisco 49ers in Week 16 of the 2025 NFL season.

Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

Indianapolis Colts quarterback Philip Rivers throws a deep 33-yard pass to wide receiver Alec Pierce.

Camryn Bynum intercepts the Brock Purdy pass vs. San Francisco 49ers, 12/22/2025

The Colts allowed 441 yards of total offense in the 48-27 loss.

Indianapolis Colts running back Jonathan Taylor sneaks into the end zone for a 1-yard touchdown.

Indianapolis Colts quarterback Philip Rivers completes a 19-yard pass to tight end Tyler Warren.

Indianapolis Colts kicker Blake Groupe makes a 51-yard field goal.

Indianapolis Colts kicker Blake Grupe drills a 39-yard field goal.

Philip Rivers with a 16-yard touchdown pass to Alec Pierce vs. San Francisco 49ers, 12/22/2025

Indianapolis Colts quarterback Philip Rivers completes a 17-yard pass to wide receiver Alec Pierce.

Indianapolis Colts quarterback Philip Rivers arcs a perfect 20-yard touchdown pass to wide receiver Alec Pierce to open the scoring on "Monday Night Football" against the San Francisco 49ers.

Indianapolis Colts quarterback Philip Rivers completes a 17-yard pass to wide receiver Josh Downs.