Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

Watch the best plays from Indianapolis Colts quarterback Philip Rivers' 277-yard, two-touchdown game against the San Francisco 49ers in Week 16 of the 2025 NFL season.

Indianapolis Colts quarterback Philip Rivers throws a deep 33-yard pass to wide receiver Alec Pierce.

Camryn Bynum intercepts the Brock Purdy pass vs. San Francisco 49ers, 12/22/2025

Indianapolis Colts running back Jonathan Taylor sneaks into the end zone for a 1-yard touchdown.

Indianapolis Colts quarterback Philip Rivers completes a 19-yard pass to tight end Tyler Warren.

Indianapolis Colts kicker Blake Groupe makes a 51-yard field goal.

Indianapolis Colts kicker Blake Grupe drills a 39-yard field goal.

Philip Rivers with a 16-yard touchdown pass to Alec Pierce vs. San Francisco 49ers, 12/22/2025

Indianapolis Colts quarterback Philip Rivers completes a 17-yard pass to wide receiver Alec Pierce.

Indianapolis Colts quarterback Philip Rivers arcs a perfect 20-yard touchdown pass to wide receiver Alec Pierce to open the scoring on "Monday Night Football" against the San Francisco 49ers.

Indianapolis Colts quarterback Philip Rivers completes a 17-yard pass to wide receiver Josh Downs.

Indianapolis Colts quarterback Philip Rivers locates running back Jonathan Taylor for a 19-yard catch and run.

From pregame moments to on-field action and sideline energy, go inside the best sights and sounds from Philip Rivers' return to the NFL with the Colts in Week 15 against Seattle.

Highlights from the Week 15 matchup between the Indianapolis Colts and the Seattle Seahawks during the 2025 NFL season.

Watch every pass attempt from Indianapolis Colts quarterback Philip Rivers from his return from retirement to the NFL.

Indianapolis Colts kicker Blake Grupe nails a go-ahead 60-yard field goal to put the Colts up 16-15 against the Seattle Seahawks with less than a minute remaining in regulations.

Indianapolis Colts wide receiver Alec Pierce makes a back shoulder catch to pick up first down yardage on a last ditch drive for the Colts.

Indianapolis Colts cornerback Mekhi Blackmon comes up with an end zone pass breakup to force the Seattle Seahawks into a go-ahead field goal attempt.

Indianapolis Colts running back Ameer Abdullah turns on the jets for a 44-yard kickoff return that ends with a hurdle over Seattle Seahawks kicker Jason Myers.

Indianapolis Colts quarterback Philip Rivers extends the Colts' lead against the Seattle Seahawks with his first touchdown pass since 2020.

Indianapolis Colts quarterback Philip Rivers connects with tight end Tyler Warren for a 17-yard gain.

Indianapolis Colts linebacker Germaine Pratt takes down Seattle Seahawks wide receiver Rashid Shaheed for a loss of 3 yards.

Indianapolis Colts kicker Blake Grupe connects on a 54-yard field goal to give the Colts a 6-3 lead against the Seattle Seahawks.

Indianapolis Colts defensive end Laiatu Latu sacks Seattle Seahawks quarterback Sam Darnold for a 7-yard loss.