Here's everything you need to know before the Indianapolis Colts take on the San Francisco 49ers in Week 7 of the 2021 NFL season.

Indianapolis Colts defensive back Khari Willis speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Indianapolis Colts defensive lineman DeForest Buckner speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Indianapolis Colts head coach Frank Reich speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Indianapolis Colts quarterback Carson Wentz speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Go on the field with quarterback Carson Wentz as he was wired for sound for the Indianapolis Colts Week 6 win over the Houston Texans.

Watch Indianapolis Colts quarterback Carson Wentz's three most improbable completions from the Week 6 win over the Houston Texans, according to Next Gen Stats.

Relive all the action at Lucas Oil Stadium as the Indianapolis Colts defeated the Houston Texans in Week 6 of the 2021 regular season.

Indianapolis Colts defensive coordinator Matt Eberflus speaks with the media ahead of the team's Week 7 matchup with the San Francisco 49ers.

Indianapolis Colts offensive coordinator Marcus Brady speaks with the media ahead of the team's Week 7 matchup with the San Francisco 49ers.

Indianapolis Colts head coach Frank Reich speaks with the media following the team's Week 6 victory over the Houston Texans.

Indianapolis Colts defensive back Isaiah Rodgers speaks with the media following the team's Week 6 victory over the Houston Texans.

Indianapolis Colts tight end Mo Alie-Cox speaks with the media following the team's Week 6 victory over the Houston Texans.

After an injury kept him sidelined for the first five weeks, Indianapolis Colts wide receiver T.Y. Hilton made his return to the field at Lucas Oil Stadium.

Indianapolis Colts head coach Frank Reich shares a message of excitement with his team following their 31-3 victory over the Houston Texans.

See the Indianapolis Colts immediate reaction as they exit the field at Lucas Oil Stadium following a victory over the Houston Texans.

Indianapolis Colts quarterback Carson Wentz speaks with the media following the team's victory over the Houston Texans.

Watch the Indianapolis Colts' top plays vs. the Houston Texans from Week 6 of the 2021 NFL Season.

Indianapolis Colts wide receiver T.Y. Hilton speaks with the media following the team's victory over the Houston Texans.

Watch every catch from Indianapolis Colts wide receiver T.Y. Hilton's return to action against the Houston Texans in Week 6 of the 2021 NFL Season.

Indianapolis Colts running back Jonathan Taylor speaks with the media following the team's victory over the Houston Texans.

Indianapolis Colts running back Jonathan Taylor's best plays from 2-TD Game in the Week 6 matchup against the Houston Texans.

Indianapolis Colts linebacker Darius Leonard speaks with the media following the team's victory over the Houston Texans.

Watch highlights from the Week 6 matchup between the Houston Texans and the Indianapolis Colts.

Watch the best passes from Indianapolis Colts quarterback Carson Wentz's 223-yard game against the Houston Texans in Week 6 of the 2021 NFL Season.