INDIANAPOLIS—It was a defensive effort that opponents don't normally have when entering Candlestick Park.
Add in a ground and pound rushing style that the 49ers defense isn't used to and that is the perfect recipe for the Colts first road victory of 2013.
Ahmad Bradshaw ran for 95 yards in leading the Colts (2-1) to a 27-7 victory over the San Francisco 49ers (1-2) on Sunday.
With the win, the Colts are now 6-0 in games following losses under Head Coach Chuck Pagano.
The Indianapolis defense was stout all afternoon in defending versatile quarterback Coin Kaepernick.
The Colts defense forced two turnovers of Kaepernick and held the 49ers signal caller to 13-of-27 and 150 yards.
Defensive coordinator Greg Manusky wanted his defense to "play faster" than they had earlier in the year in defending another mobile quarterback in Terrelle Pryor.
The unit, who was missing linebacker Pat Angerer and safety LaRon Landry, did exactly that with a disciplined effort by sacking Kaepernick three times.
On the other side of the football, the Colts offense experienced a week unlike any other losing three offensive starters to season ending injuries.
Starting center Samson Satele did not play on Sunday so the Colts interior offensive line had three starters in positions they were not in when the 2013 season started.
The Colts chewed up 179 rushing yards on 39 carries against a 49ers defense that led the NFL in rushing yards allowed over the last three years.
New running back Trent Richardson made his Colts debut and scored a touchdown on his first touch in an Indianapolis uniform.
Quarterback Andrew Luck was 18-of-27 for 164 yards and his six-yard bootleg touchdown run with 4:13 remaining gave the Colts a 20-7 lead.
Indianapolis will be back on the road next week with a trip to Jacksonville (0-3) to open up AFC South play.
FIRST QUARTER (11:20 remaining)
The Colts wasted no time in marching down the field for their opening drive touchdown. Andrew Luck was a perfect 5-of-5 for 48 yards on the drive and Trent Richardson scored on a one-yard touchdown run to get the Colts on the board. Richardson saw his first action as a Colt on a first-and-goal and two plays later he marched into the end zone on his first carry. Kicker Adam Vinatieri hit the extra point. Colts 7, 49ers 0
FIRST QUARTER (4:13 remaining)
Behind a committed ground attack, the 49ers got on the board with a 13-yard touchdown run by Kendall Hunter. Pro Bowl running back Frank Gore had three carries for 54 yards on the drive before Hunter finished it off on a second-and-goal from the 13-yard line. 49ers kicker Phil Dawson converted the extra point. Colts 7, 49ers 7
SECOND QUARTER (7:00 remaining)
After the Colts reversed field positioning, Vinatieri would hit a 43-yard field goal to give him a field goal in 39 different NFL stadiums. The field goal came after a big catch from Darrius Heyward-Bey for 19 yards. DHB has four catches for 52 yards on the afternoon.Colts 10, 49ers 7
THIRD QUARTER (6:46 remaining)
The Colts took their first drive of the second half into 49ers territory before settling for a 41-yard field goal by Vinatieri. The drive included a 15-yard scramble by Luck and a 16-yard run by Donald Brown. A 14-yard reception by Reggie Wayne pushed the Colts into field goal territory before the drive stalled. Colts 13, 49ers 7
FOURTH QUARTER (4:13 remaining)
With a pound and ground attitude, the Colts offense put together a seven-minute touchdown drive largely on the legs of Ahmad Bradshaw. Luck sealed the drive off with a six-yard bootleg touchdown run but that was set up with Bradshaw and the offensive line carving up the 49ers rush defense. Bradshaw has 16 carries for 87 yards. Vinatieri hit the extra point. Colts 20, 49ers 7
FOURTH QUARTER (2:55 remaining)
It was a dominant defensive effort out of the Colts and the unit set up the final touchdown. Inside linebacker Jerrell Freeman forced a Colin Kaepernick fumble and Kavell Conner fell on the loose ball at the 49ers eight-yard line. From there, it was Bradshaw on a one-yard touchdown run. Colts 27, 49ers 7