Indianapolis Colts head coach Frank Reich spoke with Larra Overton ahead of the team's matchup with the San Francisco 49ers.

The Indianapolis Colts travel to the Bay Area for a Sunday Night Football matchup with the San Francisco 49ers.

The Indianapolis Colts are fired up ahead of their Sunday Night Football matchup with the San Francisco 49ers.

Hear from the Indianapolis Colts players as they speak with the media ahead of their Sunday Night Football matchup with the San Francisco 49ers.

Indianapolis Colts offensive lineman Eric Fisher speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Indianapolis Colts head coach Frank Reich speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Indianapolis Colts running back Jonathan Taylor gives insight on his strong performance on Monday Night Football in Week 5.

Ahead of their Week 7 matchup, watch highlights from the Indianapolis Colts win over the San Francisco 49ers in 2005.

Indianapolis Colts defensive end Dayo Odeyingbo speaks with the media ahead of the team's Week 7 matchup with the San Francisco 49ers.

Indianapolis Colts running back Jonathan Taylor speaks with the media ahead of the team's Week 7 matchup with the San Francisco 49ers.

Indianapolis Colts wide receiver T.Y. Hilton speaks with the media ahead of the team's Week 7 matchup with the San Francisco 49ers.

Indianapolis Colts linebacker Darius Leonard speaks with the media ahead of the team's Week 7 matchup with the San Francisco 49ers.

Here's everything you need to know before the Indianapolis Colts take on the San Francisco 49ers in Week 7 of the 2021 NFL season.

Indianapolis Colts defensive back Khari Willis speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Indianapolis Colts defensive lineman DeForest Buckner speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Indianapolis Colts head coach Frank Reich speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Indianapolis Colts quarterback Carson Wentz speaks with the media ahead of the team's matchup with the San Francisco 49ers.

Go on the field with quarterback Carson Wentz as he was wired for sound for the Indianapolis Colts Week 6 win over the Houston Texans.

Watch Indianapolis Colts quarterback Carson Wentz's three most improbable completions from the Week 6 win over the Houston Texans, according to Next Gen Stats.

Relive all the action at Lucas Oil Stadium as the Indianapolis Colts defeated the Houston Texans in Week 6 of the 2021 regular season.

Indianapolis Colts defensive coordinator Matt Eberflus speaks with the media ahead of the team's Week 7 matchup with the San Francisco 49ers.

Indianapolis Colts offensive coordinator Marcus Brady speaks with the media ahead of the team's Week 7 matchup with the San Francisco 49ers.

Indianapolis Colts head coach Frank Reich speaks with the media following the team's Week 6 victory over the Houston Texans.

Indianapolis Colts defensive back Isaiah Rodgers speaks with the media following the team's Week 6 victory over the Houston Texans.

Indianapolis Colts tight end Mo Alie-Cox speaks with the media following the team's Week 6 victory over the Houston Texans.