» WR: Michael Pittman Jr., Amari Rodgers
» LT: Bernhard Raimann
» LG: Quenton Nelson, Arlington Hambright
» C: Ryan Kelly, Wesley French, Ike Boettger
» RG: Will Fries, Josh Sills
» RT: Braden Smith, Blake Freeland
» TE: Mo Alie-Cox, Drew Ogletree
» TE: Kylen Granson, Will Mallory
» WR: Josh Downs, Isaiah McKenzie
» WR: Alec Pierce, Juwann Winfree
» QB: Gardner Minshew, Sam Ehlinger
» RB: Jonathan Taylor, Zack Moss, Trey Sermon
- Following the Colts Week 5 against the Tennessee Titans, it was announced that Anthony Richardson was going to be placed on injured reserve as he recovers from his AC joint injury to his right shoulder.
- Josh Downs scored his first-career touchdown in Week 6 against the Jacksonville Jaguars.
» DE: Kwity Paye, Tyquan Lewis, Jake Martin
» DT: DeForest Buckner, Adetomiwa Adebawore
» NT: Taven Bryan, Eric Johnson II
» DE: Samson Ebukam, Dayo Odeyingbo, Isaiah Land
» WLB: Shaquille Leonard, Grant Stuard
» MLB: Zaire Franklin, Segun Olubi
» SAM: E.J. Speed, Cameron McGrone
» CB: JuJu Brents
» FS: Rodney Thomas II, Trevor Denbow
» SS: Julian Blackmon, Nick Cross
» N: Kenny Moore II, Tony Brown
» CB: Jaylon Jones, Darrell Baker Jr.
- On Tuesday, it was announced that defensive tackle Grover Stewart was suspended by the NFL for six games for violating the league's performance-enhancing substance policy.
- JuJu Brents secured his first interception of the season in Week 6 against the Jacksonville Jaguars.
» P: Rigoberto Sanchez
» PK: Matt Gay
» H: Rigoberto Sanchez
» LS: Luke Rhodes
» KR: Isaiah McKenzie, Josh Downs, Amari Rodgers
» PR: Isaiah McKenzie, Josh Downs, Amari Rodgers