INDIANAPOLIS – A pair of angry teams will meet late Sunday afternoon at Candlestick Park when the Indianapolis Colts (1-1) take on the San Francisco 49ers (1-1).
For the 49ers, the home environment will be a far cry from what they experienced in Sunday night's 29-3 defeat at Seattle.
San Francisco never found its rhythm on Sunday night, a game that included a weather delay.
It was a stark contrast to the opening week of the regular season in which quarterback Colin Kaepernick threw for 412 yards, three touchdowns and no interceptions.
The 49ers outlasted the Green Bay Packers 34-28 in Week One and the offensive look from San Francisco was reminiscent of what the entire NFC saw during the 49ers 2012 Super Bowl run.
For the second times in three weeks, the Colts will encounter a read-option look from the opposing offense.
While Kaepernick is more likely to throw than Oakland's Terrelle Pryor, the lanky 49ers quarterback still leads the team in rushing after two games in 2012.
San Francisco possesses arguably the league's top offensive line but is still looking to establish former Pro Bowl back Frank Gore.
New wide receiver Anquan Boldin is a familiar face to Colts fans. Boldin had 145 receiving yards for the Ravens in last year's AFC Divisional match up with the Colts.
49ers defensive coordinator Vic Fangio was Stanford's defensive coordinator in 2010 so he knows what he will be game planning against in Andrew Luck.
Outside linebacker Aldon Smith already has 3.5 sacks in 2013 and has a total of 37.5 sacks in his three NFL seasons.
Smith is part of the 49ers four-man linebacker group that includes All-Pros Ahmad Brooks, NaVorro Bowman and Patrick Willis.
Since 2011 (when Jim Harbaugh and Fangio took over), the 49ers defense leads the NFL in points per game and yards per carry.
*2013 Record: *1-1, Tied for 2nd in the NFC West.
*Head Coach: *Jim Harbaugh, 3rd season as 49ers head coach and third NFL season as head coach (25-8-1 overall regular season).
*2013 NFL Rankings: *Offense – Overall, 18th (350.5); Rushing, 17th (95.0); Passing, 18th (255.5) Defense – Overall, 13th (337.5); Rushing, 24th (117.5); Passing, 10th (220.0).
*2013 Leading Passer *Colin Kaepernick (40-of-67 comp., 539 yards, 59.7 pct., 3 TD, 3 INT).
*2013 Leading Rusher: *Colin Kaepernick (16 carries, 109 yards, 0 TD).
*2013 Leading Receiver: *Anquan Boldin (14 receptions, 215 yards, 1 TD).
2013 Leading Sacker: Aldon Smith (3.5).
2013 Turnover Breakdown: -2 (tied for 25th).
2013 NFL Draft Results: The 49ers were dealing all through the three days of April's NFL Draft. First-round pick Eric Reid has filled Dashon Goldson's void at safety and has been tremendous despite leaving Sunday night's loss with a head injury. San Francisco had one of the most interesting picks of the draft when it chose South Carolina running back Marcus Lattimore with the No. 131 pick. A total of seven rookies are currently on the 49ers 53-man roster.
*2012 Review: *It was a tremendous second season for Jim Harbaugh and the San Francisco 49ers. After coming a game short of the Super Bowl in Harbaugh's first season, the 49ers reached the sport's ultimate game last year. The 49ers were 11-4-1, had nine Pro Bowls and appear to have found a franchise quarterback in the dynamic Colin Kaepernick. San Francisco rode a high-scoring offense and six defensive All-Pros to within a play of capturing Super Bowl XLVII.
Last time in Playoffs: 2012 season. Lost to the Baltimore Ravens 34-31 in Super Bowl XLVII*.Last time in Super Bowl: *2013. Lost Super Bowl XLVII to the Baltimore Ravens.
*Super Bowl Championships: *Five. 1981, 1984, 1988, 1989 and 1994.
2013 Pro Bowl Selections: ILB-NaVorro Bowman, FS-Dashon Goldson, RB-Frank Gore, OG-Mike Iupati, OLB-Aldon Smith, DE-Justin Smith, OT-Joe Staley, SS-Donte Whitner, ILB-Patrick Willis.