» WR: Michael Pittman Jr., Amari Rodgers
» LT: Bernhard Raimann
» LG: Quenton Nelson, Arlington Hambright
» C: Ryan Kelly, Wesley French
» RG: Will Fries, Josh Sills
» RT: Braden Smith, Blake Freeland
» TE: Mo Alie-Cox, Drew Ogletree
» TE: Kylen Granson, Will Mallory
» WR: Josh Downs, Isaiah McKenzie
» WR: Alec Pierce
» QB: Anthony Richardson, Gardner Minshew, Sam Ehlinger
» RB: Zack Moss, Trey Sermon, Jake Funk
- Center Ryan Kelly and left tackle Bernhard Raimann were inactive for the Week 4 game against the Los Angeles Rams. Wesley French and Blake Freeland started in their place.
- Tight end Drew Ogletree led all pass catchers with three catches for 48 yards and a touchdown against the Rams. That touchdown was the first of his NFL career.
» DE: Kwity Paye, Tyquan Lewis, Jake Martin
» DT: DeForest Buckner, Taven Bryan
» NT: Grover Stewart, Eric Johnson II, Adetomiwa Adebawore
» DE: Samson Ebukam, Dayo Odeyingbo, Isaiah Land
» WLB: Shaquille Leonard, Grant Stuard
» MLB: Zaire Franklin, Segun Olubi
» SAM: E.J. Speed, Cameron McGrone
» CB: JuJu Brents
» FS: Rodney Thomas II, Trevor Denbow
» SS: Julian Blackmon, Nick Cross
» N: Kenny Moore II, Tony Brown
» CB: Jaylon Jones OR Darrell Baker Jr.
- Cornerback Dallis Flowers will miss the remainder of the season with an Achilles injury. In addition to starting on defense, he also was the team's primary kick returner.
- Defensive end Dayo Odeyingbo led all defensive linemen with seven tackles 1.5 sacks and four quarterback hits.
» P: Rigoberto Sanchez
» PK: Matt Gay
» H: Rigoberto Sanchez
» LS: Luke Rhodes
» KR: Isaiah McKenzie, Josh Downs, Amari Rodgers
» PR: Isaiah McKenzie, Josh Downs, Amari Rodgers