Official Colts Mobile App

Go behind the scenes at State Farm Stadium as the Indianapolis Colts defeated the Arizona Cardinals in Week 16.

See the best images from the Indianapolis Colts Christmas victory over the Arizona Cardinals.

See the Indianapolis Colts celebrate their Christmas victory over the Arizona Cardinals in Week 16.

Indianapolis Colts quarterback Carson Wentz speaks with the media following the team's victory over the Arizona Cardinals.

Indianapolis Colts head coach Frank Reich speaks with the media following the team's victory over the Arizona Cardinals.

Indianapolis Colts defensive lineman DeForest Buckner speaks with the media following the team's victory over the Arizona Cardinals.

Indianapolis Colts defensive end Dayo Odeyingbo speaks with the media following the team's victory over the Arizona Cardinals.

Indianapolis Colts offensive lineman Chris Reed speaks with the media following the team's victory over the Arizona Cardinals.

The Indianapolis Colts learned throughout the day Saturday that All-Pro linebacker Darius Leonard and starting strong safety Khari Willis would have to miss that night's major late-season road matchup against the Arizona Cardinals and their MVP-caliber quarterback, Kyler Murray. With several others stepping in to major roles, the Colts' defense held strong, limiting the Cardinals to just 16 points in a huge 22-16 Week 16 victory.

Indianapolis Colts head coach Frank Reich shares a message with his team following their victory over the Arizona Cardinals in Week 16.

See the Indianapolis Colts' instant reaction to their win over the Arizona Cardinals on Christmas.

Watch all of the best throws made by Indianapolis Colts quarterback Carson Wentz from his two-touchdown game in Week 16 of the 2021 season.

Watch the game highlights between the Indianapolis Colts and the Arizona Cardinals from Week 16 of the 2021 season.

Watch the best plays by the Indianapolis Colts against the Arizona Cardinals in Week 16 of the 2021 NFL season.

Watch all of the best runs made by Indianapolis Colts running back Jonathan Taylor from his 108-yard game in Week 16 of the 2021 season.

Indianapolis Colts wrap up Christmas win with onside kick recovery.

The Colts are in Arizona for a Christmas night matchup against the 10-4 Cardinals at State Farm Stadium. Follow along with writer JJ Stankevitz for updates all game long. 

See all the action on the field at State Farm Stadium as the Indianapolis Colts face the Arizona Cardinals in Week 16.

Indianapolis Colts quarterback Carson Wentz throws a 14-yard touchdown pass to wide receiver Dezmon Patmon.

Indianapolis Colts quarterback Carson Wentz drops 38-yard dime on the run to wide receiver T.Y. Hilton.

Indianapolis Colts tight end Mo Alie-Cox races up sideline for 37-yard catch and run.

Indianapolis Colts offensive guard Danny Pinter pushes running back Jonathan Taylor ahead for a gain of eight yards.

Indianapolis Colts wide receiver Michael Pittman Jr. caps 14-yard catch and run by hurdling upright DB.

Arizona Cardinals quarterback Kyler Murray gets called for intentional grounding in the end zone resulting in a safety and two points for the Indianapolis Colts.

Indianapolis Colts running back Nyheim Hines uses all his finger strength for impressive catch.

Indianapolis Colts quarterback Carson Wentz zips a 23-yard rocket to a diving wide receiver Ashton Dulin.

Indianapolis Colts quarterback Carson Wentz throws a touchdown pass to wide receiver T.Y. Hilton on the Colts' first drive.

Indianapolis Colts running back Jonathan Taylor wastes no time taking first touch of game for explosive 43-yard run.

See the Indianapolis Colts warmup at State Farm Stadium as they prepare to face the Arizona Cardinals in Week 16.

The Indianapolis Colts have arrived at State Farm Stadium ahead of their matchup on Christmas against the Arizona Cardinals.

Indianapolis Colts head coach Frank Reich speaks with Larra Overton about his team's matchup with the Arizona Cardinals in Week 16.

The Indianapolis Colts have boarded the planed to travel to Arizona for their Week 16 matchup with the Arizona Cardinals.

The Indianapolis Colts travel west to the desert for a Christmas matchup with the Arizona Cardinals as the teams are set to square off on Saturday Night Football in Week 16.

Hear from the Indianapolis Colts as they speak with the media ahead of their Week 16 matchup with the Arizona Cardinals.

Indianapolis Colts head coach Frank Reich announces that Mark Glowinksi has been placed on the Reserve/COVID-19 list and rules out Ryan Kelly and Andrew Sendejo ahead of the team's matchup with the Arizona Cardinals.

Pick Six presented by Caesars Sportsbook is a free-to-play game on the Colts App

Each week, fans will answer a series of six questions with their predictions for the game and compete for their chance to win exclusive autographed items and other Colts prizes. All players will also be entered for a chance to win a VIP trip to a Caesars property in Las Vegas. Enter today in the Colts mobile app and play each week all season long.

Must be 21 or older to participate.

Jonathan Taylor's MVP-caliber season will continue when the Colts take on the Cardinals in Week 16, Next Gen Stats show why Arizona's defense will struggle to contain him.

Indianapolis Colts wide receiver T.Y. Hilton speaks with the media ahead of the team's matchup with the Arizona Cardinals.

Indianapolis Colts linebacker Darius Leonard speaks with the media ahead of the team's matchup with the Arizona Cardinals.

Indianapolis Colts running back Jonathan Taylor speaks with the media ahead of the team's matchup with the Arizona Cardinals.

Indianapolis Colts quarterback Carson Wentz speaks with the media ahead of the team's matchup with the Arizona Cardinals.

Indianapolis Colts head coach Frank Reich speaks with the media ahead of the team's matchup with the Arizona Cardinals.

Indianapolis Colts linebacker Zaire Franklin speaks with the media ahead of the team's matchup with the Arizona Cardinals.

Indianapolis Colts defensive lineman DeForest Buckner speaks with the media ahead of the team's matchup with the Arizona Cardinals.

All the ways Colts fans can watch, live stream and listen to Indianapolis Colts at Arizona Cardinals on Saturday, December 25th 2021 (Week 16).

Indianapolis Colts offensive coordinator Marcus Brady speaks with the media ahead of the team's matchup with the Cardinals.

Indianapolis Colts defensive coordinator Matt Eberflus speaks with the media ahead of the team's matchup with the Cardinals.

Indianapolis Colts special teams coordinator Bubba Ventrone speaks with the media ahead of the team's matchup with the Cardinals.

Don't miss out on an exciting lineup of gameday events. Here's everything Colts Nation can look forward to as the season continues.

The Colts will take on the Cardinals on Christmas in Glendale. Here's what you need to know about Arizona's offseason and what to expect in 2021. 

Get a look at the new additions to the Arizona Cardinals ahead of their week 16 matchup with the Colts.

See the Indianapolis Colts full 17-game schedule in photos ahead of the upcoming 2021 season.