Indianapolis Colts At Buffalo Bills, November 21, 2021

On Sunday Nov. 21, the Indianapolis Colts will face the Buffalo Bills at Highmark Stadium in week 11 of the 2021 NFL regular season.

WEEK 11 • SUN 11/21 • FINAL

Indianapolis Colts 6-5

Buffalo Bills 6-4

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In Week 11, the Colts will travel to Buffalo. The Bills own a 37-32-1 all-time regular season record against the Colts and are 23-13 at home. The game will be a rematch of the 2020 AFC Wild Card Round game where Buffalo hosted and defeated Indianapolis, 27-24. In their last regular season matchup in Week 7 of the 2018 season, the Colts hosted and defeated the Bills, 37-5. Linebacker Darius Leonard led all players with 17 tackles (12 solo) and added one fumble recovery. Running back Marlon Mack registered 19 carries for 126 yards and one touchdown. Wide receiver T.Y. Hilton tallied two receiving touchdowns.

Players & Coaches To Know

Indianapolis Colts

Buffalo Bills

2020 record: 13-3

2021 additions: WR Emmanuel Sanders, P Matt Haack, QB Mitchell Trubisky, DE Efe Obada, OLB Tyrell Adams, RT Bobby Hart, TE Jacob Hollister, OG Forrest Lamp, RB Matt Breida, OG Jamil Douglas, DT Trayvon Hester, WR Brandon Powell, LB Joe Giles-Harris

2021 losses: WR Andre Roberts, WR John Brown, DT Quinton Jefferson, TE Tyler Kroft, RT Ty Nsekhe, OG Brian Winters, S Dean Marlowe, P Corey Bojorquez, LB Del'Shawn Phillips, TE Lee Smith

2021 draft class: EDGE Gregory Rousseau, EDGE Carlos Basham Jr., OL Spencer Brown, OL Tommy Doyle, WR Marquez Stevenson, S Damar Hamlin, CB Rachad Wildgoose, OL Jack Anderson,

All-Time series: 32-38-1

Last matchup: Wild Card Round 2020 at Bills Stadium - Bills 27, Colts 24

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