Indianapolis Colts At San Francisco 49ers, October 24, 2021

On Sunday Oct. 24, the Indianapolis Colts will face the San Francisco 49ers at Levi's Stadium in week 7 of the 2021 NFL regular season.

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In Week 7, the Colts will travel to San Francisco to play the 49ers on Sunday Night Football. It will mark the 45th all-time regular season meeting between the teams with Indianapolis leading the series at 26-18 (11-11 in San Francisco). The game will also be the first for the Colts at Levi's Stadium. In Week 5 of the 2017 season, the Colts hosted the 49ers and won in overtime, 26-23. Wide receiver T.Y. Hilton led all players with 177 receiving yards on seven receptions. Then rookie running back Marlon Mack registered nine carries for 91 yards and one touchdown.

2020 record: 6-10

2021 additions: C Alex Mack, OLB Samson Ebukam, DE Zach Kerr, WR Mohammed Sanu, S Tavon Wilson, DT Maurice Hurst, DE Arden Key, RB Wayne Gallman, QB Nate Sudfeld, OLB Nate Gerry, WR Bennie Fowler

2021 losses: WR Kendrick Bourne, DE Kerry Hyder, QB C.J. Beathard, CB Akhello Witherspoon, DE Solomon Thomas, WR Marquise Goodwin, RB Tevin Coleman, RB Jerrick McKinnon, LB Joe Walker, WR Trent Taylor

2021 draft class: QB Trey Lance, OL Aaron Banks, RB Trey Sermon, CB Ambry Thomas, OL Jaylon Moore, CB Deommodore Lenoir, S Talanoa Hufanga, RB Elijah Mitchell

All-Time series: 26-18

Last matchup: Week 5, 2017 at Lucas Oil Stadium - Colts 26, 49ers 23 (OT)

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