The Indianapolis Colts will host the New Orleans Saints in their first matchup since 2011. Game time is set for 1 p.m. at Lucas Oil Stadium.
The contest will mark the 12th all-time meeting between the teams in the regular season, with the Saints holding a 6-5 advantage.
Last week, the Colts hosted the defending Super Bowl champion New England Patriots and lost, 34-27.
Colts quarterback Andrew Luck returned to the field for the first time since Week 3. The offense scored on the opening possession of the game as Luck completed a five-yard touchdown pass to wide receiver Donte Moncrief.
New England put 10 points on the board before safety Mike Adams intercepted Tom Brady and returned the ball 14 yards for a touchdown. The Patriots and Colts then traded touchdowns before Stephen Gostkowski hit a field goal to give New England a 21-20 advantage entering halftime.
The Patriots scored two second half touchdowns to extend their lead to 34-21. The Colts attempted a late rally as Luck (30-of-50 for 312 yards and three touchdowns) threw his final touchdown of the game to wide receiver Griff Whalen to cut the deficit to 34-27.
The Colts attempted an onside kick but failed to recover the ball as the Patriots clinched the victory.
Following Sunday's game, the Colts will travel to face the Carolina Panthers on ESPN's Monday Night Football.