Waived were: Running back Lance Ball, wide receiver Sam Giguere, defensive lineman John Gill, defensive tackle Adrian Grady, running back Mike Hart, defensive end Marcus Howard, defensive back Dante Hughes, center Steve Justice, wide receiver John Matthews, wide receiver Brett McDermott, running back Walter Mendenhall, offensive lineman Tom Pestock, wide receiver Taj Smith, linebacker Michael Tauiliili, defensive tackle Terrance Taylor, offensive lineman Jaimie Thomas, defensive end Josh Thomas and offensive tackle Michael Toudouze. Waived-Injured were: defensive backs Nick Graham and Travis Key and tight end Jamie Petrowski.

The Colts removed safety Bob Sanders from the Physically Unable to Perform List, placing him on the 53-player active roster. Also, defensive tackle Ed Johnson will not count on the active roster until after Week One.